Cretinism is the most serious IDD and occurs when a pregnant women is severely iodine deficient. Cretinism; a type of dwarfism in which the individual retains childlike proportions and is mentally retarded. Insulin. falling hair, low basal metabolic rate, obesity (myxedema in the adult) Growth Hormone. Lantern Jaw; large hands and feet (acromegaly in the adult) Thyroxine. Bulging eyeballs, nervousness, increased pulse rate, weight loss.
Cretinism is a disease caused by hypothyroidism. Iodine deficiency in diet during pregnancy is the major cause of cretinism. Hypothyroidism leads to impaired development of the growing fetus and leads to mental retardation and stunted growth. Adult stature ranges from 1 to meters without treatment, depending on the severity of the disease, sex and other genetic factors. In adults, cretinism results in mental deterioration, swelling of the skin, loss of water and hair. Bone maturation and puberty are severely delayed. In women, ovulation is impeded and infertility is common.
Caused by iodine deficiency, cretinism was endemic in the Alps until the early 20th century. Most countries now have programmes to fight the congenital disorder, but it remains the main cause of. Congenital hypothyroidism, previously known as cretinism, is a severe deficiency of thyroid hormone in newborns. It causes impaired neurological function, stunted growth, and .
The key difference between dwarfism and cretinism is that dwarfism refers to a condition of growth retardation that causes an abnormally short adult stature while cretinism is a condition arising from the deficiency of thyroid hormone, which causes dwarfism and mental retardation. Cretinism or Congenital Hypothyroidism occurs when there are inborn anomalies in thyroid metabolism. For the production of thyroid hormones, T3 and T4, the thyroid gland uses tyrosine and iodine. The iodide is attached to the thyroid follicular cells through the active transport system.
Cretinism is a congenital disorder meaning it is present at birth. In this disorder, there is reduced or absent thyroid function as well as the production of thyroid hormone. If this condition is not treated in time, it may result in severe stunted mental and physical growth of a baby. Ahuja MM, Chopra IJ, Sridhar CB. Sporadic cretinism and juvenile hypothyroidism. Metabolism. Jun; 18 (6)– BLIZZARD RM, CHANDLER RW, LANDING BH, PETTIT MD, WEST CD. Maternal autoimmunization to thyroid as a probable cause of athyrotic cretinism. N Engl J Med. Aug 18; – GABR M.